Background:

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Applications:

WB, IHC

Name of antibody:

BIRC5

Immunogen:

Fusion protein of human BIRC5

Full name:

baculoviral IAP repeat containing 5

Synonyms:

API4; EPR-1

SwissProt:

O15392

IHC positive control:

Human liver cancer and Human gastric cancer; Human esophagus cancer and Human prostate cancer

IHC Recommend dilution:

100-500

WB Predicted band size:

16 kDa

WB Positive control:

Jurkat, SKOV3, 231 cell lysates

WB Recommended dilution:

1000-5000